Veterinary Systemic Antibacterial
Light yellow nonsterile solution containing tilmicosin phosphate equivalent to 300 mg tilmicosin per ml.
Symtil 30% Oral Solution; contains semi-synthetic macrolide antibiotic tilmicosin. Tilmicosin is especially used
in the treatment of pneumonia infections in cattle due to its high affinity for lung tissue. The mechanism of
action of tilmicosin is based on the principle of inhibiting peptide translocation by binding to the ribosomal 50S
subunit in bacteria as in antibiotics, thus inhibiting protein synthesis. Some Gram positive microorganisms and
gram negative microorganisms such as Pasteurella haemolytica, Haemophilus somnus, Pasteurella multocid,
Mycoplasma gallisepticum, M. synovia, Mycoplasma dispar and Ornithobacterium rhinotracheale are sensitive
to tilmicosin. E. coli, Enterobacter aerogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella and
Serratia spp. and Actinomyces sp. are resistant.
Just as in other macrolide antibiotics, tilmicosin has high tissue distribution characteristics despite low serum
concentration. The peak plasma level of tilmicosin given orally to broilers at 75 mg/day for 13 days was
measured as 10 μg ml. Lung tissue concentration was reported to be 2.3 μg/ml and air sac concentration to be
3.29 μg/ml, 48 hours after administration.
APPLICATIONS / INDICATIONS:
Symtil 30% Oral solution is used in the treatment of respiratory tract infections caused by Mycoplasma
gallisepticum, M. synovia, Ornithobacterium rhinotracheale, Pasteurella multocida and tilmicosin sensitive
microorganisms in chicken and turkey meat.
USE AND DOSE:
Tilmicosin is used in chicken and turkey meat as 15-20 mg/kg live weight per day. For 1000 kg live weight a
daily dose of 50-65 ml is added to the water. The application is continued for 3 days. If not advised otherwise by
the veterinarian, the dose is practically calculated as follows.
|Symtil 30% needed for one day treatment|
Oral Solution (ml)
|Number of animals x Average live weight (kg) x 15|
UNWANTED SIDE EFFECTS:
Tilmicosin may cause potentially toxic effects such as increased pulse rate on the heart and reduced strength of
The joint use of chloramphenicol, florfenicol, lincosamides and other macrolide antibiotics causes antagonism.
OVERDOSE SYMPTOMS AND ANTIDOTE
Risk of cardiac toxicity increases with overdose. Specific antidote is unknown. Beta-adrenergic receptor blockers
such as propranolol are not recommended because they reduce heart muscle contraction despite mitigation of